IGF-1 LR3 1mg

Name: IGF-1 LR3 1mg
SKU: 6415
Availability: InStock

$99.00

IGF-1 LR3 is a research peptide analog of human insulin-like growth factor 1 (IGF-1) containing a 13–amino acid N-terminal extension that enhances stability and receptor binding. It interacts with the IGF-1 receptor to activate PI3K/Akt and MAPK/ERK pathways involved in cellular growth, differentiation, and metabolic regulation. IGF-1 LR3 is used in experimental models to study peptide-mediated anabolic signaling, receptor kinetics, and tissue remodeling mechanisms.

Categories: IGF-1 Proteins, Popular Peptides

Description
Reviews (0)

IGF-1 LR3 is a synthetic, long-acting analogue of insulin-like growth factor 1 (IGF-1), a naturally occurring peptide hormone involved in growth, cell repair, and metabolism. It was engineered to extend the activity of native IGF-1 in the body and increase its resistance to binding proteins that normally limit its effects.

IGF-1 LR3 is classified as a research compound and is not an approved pharmaceutical treatment.

What IGF-1 Is in the Body

Natural IGF-1 is produced primarily in the liver in response to growth hormone signaling. It plays a central role in cell growth, protein synthesis, tissue repair, and development. IGF-1 is especially important in muscle, bone, cartilage, and nerve tissue.

In normal physiology, IGF-1 activity is tightly regulated and short-lived, ensuring controlled growth and repair rather than unchecked cell proliferation.

What Makes IGF-1 LR3 Different

IGF-1 LR3 is a modified version of natural IGF-1 with two key structural changes:

A substitution of one amino acid
An extended amino acid chain added to the molecule

These modifications significantly reduce its binding to IGF-binding proteins and increase its functional lifespan in the body. As a result, IGF-1 LR3 is more potent and longer-acting than endogenous IGF-1.

How IGF-1 LR3 Works

IGF-1 LR3 works by binding to IGF-1 receptors on cells, activating pathways involved in cell growth, differentiation, and repair. This signaling promotes protein synthesis, cellular regeneration, and nutrient uptake.

Unlike growth hormone–releasing peptides, IGF-1 LR3 acts directly at the cellular level rather than stimulating upstream hormone release. This direct mechanism is one reason it is considered significantly more powerful and biologically active.

Potential Areas of Interest

IGF-1 LR3 is commonly associated with research into:

Muscle cell growth and repair
Recovery from intense physical stress
Satellite cell activation
Nutrient partitioning and metabolism
Bone and connective tissue health
Cellular regeneration processes

These areas of interest are based on IGF-1’s established biological role and experimental research rather than approved clinical applications.

Biochemical Characteristics

Sequence: MFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPA KSA
Molecular Formula: C400H625N111O115S9
Molecular Weight: 9117.5 g/mol
CAS Number: 946870-92-4

Source: PubChem

IGF1-LR3 retains the core tertiary fold of native IGF-1 while exhibiting altered receptor-binding kinetics due to its modified N-terminal region. The peptide interacts primarily with the IGF-1 receptor (IGF-1R) and, to a lesser extent, insulin receptor isoforms. Reduced interaction with IGF-binding proteins alters distribution and degradation dynamics in experimental models.

Research Applications

IGF1-LR3 is employed in laboratory research to study mitogenic and differentiative signaling mediated by IGF-1R activation. Common applications include cell-culture assays assessing proliferation kinetics, lineage differentiation, and survival signaling in connective tissue, epithelial, neural, hepatic, and renal model systems.

Additional experimental use includes investigation of metabolic signaling interactions between IGF-1R and insulin receptor pathways, particularly in studies examining glucose transport, lipid metabolism regulation, and energy-balance signaling in animal and cellular models.

Pathway / Mechanistic Context

Mechanistically, IGF1-LR3 activates IGF-1R–dependent signaling cascades, including the PI3K–Akt and MAPK/ERK pathways. These pathways regulate transcriptional programs governing cell-cycle progression, apoptosis suppression, and differentiation signaling. Due to extended receptor engagement, IGF1-LR3 enables prolonged pathway interrogation compared to native IGF-1 in experimental settings.

Preclinical literature also describes interaction between IGF-1 signaling and myostatin-regulated pathways, with downstream effects on MyoD-associated transcription. These interactions are investigated to understand regulatory balance between growth-promoting and growth-inhibitory signaling networks in skeletal muscle models.

Preclinical Research Summary

Preclinical investigations of IGF1-LR3 include in-vitro cell-culture studies and in-vivo animal models evaluating cellular proliferation, differentiation capacity, metabolic signaling, and tissue-maintenance markers. Reported findings include increased proliferative indices, modulation of glucose uptake pathways, and altered expression of genes involved in growth regulation.

Animal studies further explore interactions between IGF-1 signaling and aging-associated pathways, glucocorticoid-responsive signaling, and metabolic adaptation under experimental conditions. All findings are interpreted strictly within the context of laboratory research models.

Reviews

There are no reviews yet.